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With multiple drugs in late-stage clinical trials, several are expected to reach regulatory approval between late 2025 and 2026, potentially marking the biggest expansion of obesity treatment options in history

S6 and S7

Charles Brenner, who discovered nicotinamide riboside as an NAD+ precursor, conducted a 2016 clinical trial showing oral NR supplementation safely increased human blood NAD+ levels up to 2.7-fold [14]

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Int J Mol Sci 19:3339 Logan RM, Stringer AM, Bowen JM, Yeoh AS-J, Gibson RJ, Sonis ST, Keefe DM (2007) The role of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugs