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In addition, GLP-1RAs can effectively upregulate the expression of myogenic regulatory factors MyoD and MyoG, while inhibiting the transcription of key ubiquitin-ligases MAFbx and MuRF1 in muscle atrophy

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Cell Metab (2021) 33(4):833844.e5

The generation of ROS by embryo metabolism or the culture medium has been demonstrated to induce a series of deleterious effects, including protein denaturation, apoptosis, autophagy, lipid oxidation, DNA damage, and mitochondrial impairment

Brain imaging studies have shown decreased volume in cortical and limbic regions, particularly in the PFC and hippocampus, in patients with MDD