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The protein levels of ATF6 were higher in the HF group as compared with the other two groups, but the difference between the HF and HF/L-LC groups was not significant ( P = 0255) (Fig

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The review concluded that NNMT plays important roles in obesity and type 2 diabetes and validated 5-Amino-1MQ as a potent small-molecule NNMT inhibitor that reverses diet-induced metabolic changes, establishing it as a primary research tool for the NNMT pathway

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