A blinded extension among participants with baseline BMI 35 reached mean weight loss of 30.3% at 104 weeks
In the context, Figure 2 shows that GLP-1RA-driven microbiota changes coordinate SCFA and bile acid signaling, promoting WAT beiging and gut-brain axis-mediated energy balance
If nausea is intolerable, the dose of the current agent may be reduced (if possible) or another class of GLP-1RA may be trialled
Mol Cell Endocrinol 297: 127136
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