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Age-related macular degeneration (AMD) manifests a complex pathogenesis characterized by intricate interactions among oxidative stress, inflammatory responses, and metabolic dysregulation [13]

Persistent Better accumulated and retained in the body than cyanocobalamin

Yanatori, I., Richardson, D

These nanoparticles simultaneously inhibit ferroptosis by chelating iron ions, scavenging free radicals, and inhibiting PDE4 enzyme to activate the cAMP/PKA pathway, thereby enhancing the survival rate of retinal ganglion cells (182)

Direct modulation of the HPO axis remains a hypothesis that requires further validation through mechanistic trials