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doi: 10.1016/S0021-9258(18)99181-7 148 PetersonCTRodionovDAOstermanALPetersonSN

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Gene x environment (GxE) interactions We quantified the resulting GxE interaction effects by calculating the Z -score of the LFC (relative to pDNA) using cutting control guides as the null distribution, which corrects for differences in growth rates between different conditions (Supplementary Data 2)

The effect of a high-fat diet on -cells is an inhibition of the increased cytosolic pH that is necessary to trigger Smad5 interaction with V-ATPase and the subsequent acidification of insulin secretory vesicles