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Emerging studies indicate that DSIP may modulate these CNS effects by improving blood flow to the brain

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The persistence of effects without continuous receptor occupation suggests DSIP may trigger gene expression changes rather than requiring constant pharmacological presence

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Also, anxiety-like behavior was measured in the EPM [37, 40], DLB [34, 42], OFT [34], and hole board test (HBT) [37], and memory in the object recognition test (ORT) [42]