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Int J Rad Oncol Biophys 54:45-50, 2002

As Healio previously reported, once-weekly semaglutide conferred a 14.9% weight reduction at 68 weeks for adults with obesity in the STEP 1 trial, and tirzepatide was tied to up to 20.9% weight loss at 72 weeks in the SURMOUNT-1 trial

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In OA and other inflammation-related diseases, NF-KB activation commonly leads to decreased transcription of antioxidant factors such as GPX4, NQO1, and HMOX1, thereby promoting ferroptosis (124, 125)

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