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Molecular docking was performed with AutoDock Vina 1.2.0 73 using default settings, except for increasing the exhaustiveness to 32

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline Solubility: 2.08 mg/mL (4.17 mM)

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Because Wegovy (when approved at its highest dose) produces rapid weight loss and sharper metabolic shifts, this could drive the stronger association by predisposing to optic nerve hypoperfusion through intravascular volume contraction, hypotension with nocturnal dips and autonomic instability. For ophthalmologists, the findings highlight a potential safety signal that warrants further investigation but should be interpreted cautiously

Vitamin B12 also has a well-established history of effective subcutaneous absorption