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Other GLP-1-targeted drugs including Eli Lilly's tirzepatide and Boehringer Ingelheim's survodutide have also shown promise in MASH, suggesting there could be multiple treatment options in the next couple of years

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236 The oxidation cycle of both Prxs and GSH is directly influenced by the availability of redox cofactor NADPH, suggesting that NADPH metabolism might play a vital role in controlling redox rhythmic and transcriptional oscillations

If you experience side effects, consult your prescriber for evidence-based management strategies

This shift in energy metabolism is consistent with mitochondrial impairment, which forces cells to rely more heavily on glycolysis, producing lactate as a by-product