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Functional enrichment indicated strong activation of iron transport and lipid peroxidation pathways, but weak engagement of glutathione metabolism, suggesting selective vulnerability to iron-driven oxidative stress
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Funding This study was funded by the High Level Chinese Medical Hospital Promotion Project (HLCMHPP2023089), the Special Programme for the Cultivation of Outstanding Young Scientific and Technological Talents (Innovation Category) under the Basic Scientific Research Fund of China Academy of Chinese Medical Sciences (ZZ13-YQ-019), and the Fundamental Research Funds for the Central Public Welfare Research Institutes (ZZ-YQ2023004)
A patients response may depend on: Starting weight Insulin resistance Appetite patterns Hormone changes Sleep quality Stress levels Muscle mass Nutrition habits Medication tolerance Dose progression Follow-up consistency Some patients begin comparing medications after a plateau, when semaglutide or tirzepatide results may slow over time and the treatment plan needs to be reassessed
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