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Semaglutide works by mimicking a natural hormone in the body called GLP-1, which helps regulate appetite and blood sugar levels, leading to reduced hunger and increased feelings of fullness

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The suppressed hepatic glucose production and expression of gluconeogenic genes induced by intracerebral ventricular insulin infusion is impaired in liver-specific STAT3 deficiency mice and in IL-6 deficient mice (Inoue et al., 2006)

There are other anorectic hormones that instead work rapidly, signaling our brain on more of a meal-to-meal basis

This makes nutritional intake critical, necessitating frequent healthcare check-ins