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In another trial using the same dose, a significant increase in resting energy expenditure of 6.4% (111 kcal/24 h) was reported (NCT01867437) ( Table 2 ) (88, 89)

Before approval, compounds are investigational and continue to be studied through controlled research programs

GPX4 plays a vital role not only in the system Xc- pathway but also in the lipid peroxidation pathway [54, 55]

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