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Insulin resistance alters renal tubular function, reducing urinary pH and citrate excretion (citrate normally inhibits stone formation) whilst increasing calcium excretion

It causes damage to the blood vessels in the retina and may result in vision loss

Research applications include melanocortin receptor characterization, receptor selectivity investigations, structure-activity relationship studies, and comparative analyses of melanocortin receptor agonists

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(PubMed) DeRitter E, Cohen N, Rubin SH