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The original genetic-validation study used antisense oligonucleotide-mediated knockdown of NNMT in adipose tissue of mice on a high-fat diet, with whole-body and adipose-tissue metabolic endpoints measured against scrambled-oligonucleotide controls [2]
Hypoxia promotes the production of several gene products implicated in tumor development, invasion, and metastasis formation of gastric cancer
Interestingly, the proteins encoded by these genes are cytosolic (Figure 2), even though the initial location of oxidant generation in several of the studies shown in Figure 4 is expected to be mainly peroxisomal ( cat2 ) or chloroplastic (paraquat, flu )