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Unlike traditional human growth hormone therapy, which can cause increased levels of insulin-like growth factor-1 (IGF-1) and affect blood sugar regulation, AOD-9604 is designed to target fat cells directly

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3.8 Risk and bias assessment Based on the Cochrane risk assessment tool, 3 (23%) studies did not mention the random sequence generation method and 4 (31%) did not mention the allocation concealment

But the hard cardiovascular events came in below expectations in both arms, and the MACE analyses, while pre-specified, were not sized to prove event reduction (MACE-5 hazard ratio 0.82, confidence interval crossing 1)