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About 10% of tirzepatide participants had a heart-rate increase above 20 bpm during escalation, compared with 3% on placebo. A lean Japanese cohort reached +10 to +13 bpm, and 23% of Japanese participants at 15 mg crossed the abnormal-pulse threshold versus 7% of other participants, despite only 17% higher exposure. Lean and East Asian bodies showed greater cardiovascular sensitivity than exposure alone predicted
Novo Nordisk is using this strategy to defend and extend its obesity leadership beyond semaglutide alone
B3): This B vitamin improves cholesterol levels and lowers cardiovascular risks
Mistake #4: Taking cyanocobalamin with MTHFR mutation The fix: If you have MTHFR, use methylcobalamin its already methylated and bypasses your genetic bottleneck
PMID: 13 SchneiterPTappyL
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