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J Alzheimers Dis 83(2):799818 Caruso I, Giorgino F (2024) Renal effects of GLP-1 receptor agonists and tirzepatide in individuals with type 2 diabetes: seeds of a promising future

Unlike thalidomide, which was once promoted for its extreme safety prior to the discovery of its teratogenicity, acetaminophen has a long history of serious side effects associated with its use (Table 1)

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While its prescribed for medical conditions, using it for muscle growth is considered off-label and may be subject to stricter laws

Multiple safety and research bodies have weighed in: World Health Organization (WHO) : In June 2025, WHO issued a medical product alert highlighting NAION as a potential risk associated with semaglutide (Ozempic, Rybelsus, Wegovy)