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NRF2 coordinates with several antioxidant pathways in response to oxidative stress (Figure 2)

These context-dependent effects of cellular processes, transcription factors, and metabolites are present in many aspects of biology, influenced by the concomitant expression of receptors, metabolic enzymes/pathways of each cell, molecular partners, and convergent or divergent signaling/ transcription factors activation

A small single-dose human study supports absorption and rapid conversion

doi: 10.1172/JCI143645 39

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