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Thus, experimental approaches that isolate NMDAR-specific mechanisms by holding nicotinic transmission constant are essential to determine whether KYNA-NMDAR interactions confer context-dependent benefits, particularly through the attenuation of glutamate-driven excitotoxicity

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Additionally, funding agencies can also consider funding for degradation and toxicity studies that use high dimensional techniques such as siRNA seq, mass cytometry, and special transcriptomics to demonstrate single cell and tissue level toxicity of degradation products