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A translational review on NNMT inhibitor clinical development ( Emerging opportunities for NNMT inhibitor clinical translation , ScienceDirect, 2026) points out that alternative routes like polyamine biosynthesis could compensate for the raised SAM, and that partial rather than total inhibition might even be preferable specifically to avoid triggering those compensatory mechanisms from a chronically imbalanced SAM/SAH ratio

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10.1038/nn.4025 Summary Keywords Alzheimerrs disease, GLP-1 agonists, estrogens, prevention, metabolism Citation Lizcano F, Sanabria D and Aviles E (2025) Hormonal modulation, mitochondria and Alzheimers prevention: the role of GLP-1 agonists and estrogens

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