EAAT3 knockdown increases ROS and enhances sensitivity to ferroptosis in lung cancer
R.PuranikA
Vitamin B12, also known as cobalamin, plays a crucial role in: Red blood cell production Nerve function DNA synthesis Energy production and metabolism A deficiency in Vitamin B12 can lead to fatigue, anemia, nerve damage, and cognitive issues
The S-hexyl and S-2-iodobenzyl moieties of these product analogs bind in a pocket defined by side-chains from the beta1-alpha1 loop (Tyr7, Trp8, Ile10, Gly12, Leu13), helix alpha4 (Arg103, Tyr104, Ser107, Tyr111), and the C-terminal coil (Gln204, Gly205, Trp206, Gln207)
Methods Cell lines and cell culture Murine WEHI, 32D (32Dcl3), WT, and T315I-BcrAbl-transformed 32D cells were generously provided by Dr