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These interventions aim to restore intestinal microecological balance, increasingly recognized as pivotal in the pathophysiology of these conditions

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Concurrently, sUA mediates the degradation pathway of the IRS2 protein and activates Adenosine 5-monophosphate (AMP)-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) in macrophages, thereby reducing energy consumption which leads to IR (60)

The body weight of normal control rats and HCD rats increased by 8.03 and 16.82% after 7th week respectively

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