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The underlying mechanism is unknown, but may be related to the estrogen-like effect of tamoxifen

In a pioneering attempt to elucidate the molecular mechanisms of inhibitory synaptic plasticity, Nusser and colleagues (Nusser et al., 1998) used a combination of quantal analysis of evoked inhibitory postsynaptic currents with quantitative immunogold labeling of synaptic GABA A Rs in hippocampal granule cells

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