K., Palit, A., Parkman, H
The artificial GLP-1 you inject is not the same as your own homegrown GLP-1, also known as endogenous GLP-1
As an insulinotropic hormone, GLP-1 plays a substantial role in the regulation of glucose homeostasis, not only in the periphery but also in the central nervous system [90]
Intriguingly, GLP-1 is secreted by intestinal cells not only in response to food but also to "inflammatory stimuli," and its levels correlate with disease severity in inflammation
While challenges with adherence, side effects, and weight regain upon discontinuation have prompted the search for additional strategies, targets like GLP-1R, GIPR, and GDF8 (Myostatin) still remain the most highly relevant and active areas of research for developing effective obesity treatments