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(1998) at Novo Nordisk (original designation NNC 26-0161) as a selective agonist of the growth-hormone-secretagogue receptor GHSR-1a

Initial laboratory evaluation revealed severe hyponatremia with a serum sodium concentration of 104 mEq/L (reference range: 135-150 mEq/L)

10.1111/j.1469-8137.1996.tb01856.x 159 ZhangH.WangJ.AllenR

Ang II elevates catecholamines in the periphery and central, and pretreatment with Ang II receptor antagonism losartan significantly attenuates neuroendocrine responses, indicating Ang II activates sympathetic-adrenomedullary system activity through AT1R during stress (180)