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2015;10:e0141572

As clinicians continue to address the growing overlap between obesity, diabetes, and chronic pain, GLP-1 therapies are attracting attention as a potentially broader metabolic intervention

Moreover, it is required for the transport and metabolism of fats and cholesterol within the body, which is important for the healthy support of the endocrine, cardiovascular and hepatic systems

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The present review summarizes the signaling mechanisms that contribute to drug abuse-related BBB dysfunction (Figure 1)