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Confirmatory secondary endpoints are change from baseline in AD Cooperative Study Activities of Daily Living MCI (ADCS-ADL-MCI) score and time to progression to a CDR global score of 1.0 among participants with a CDR global score of 0.5 at baseline, both assessed at week 104 (see discussion and Table 2)

Surprisingly, in one recent study, robust expression of the GLP-1 receptor mRNA was also reported in human cardiac ventricles, but the exact localization of the GLP-1R protein could not be determined [613]

Tirzepatide mimics both GLP-1 and GIP hormones, potentially offering greater weight loss than semaglutide alone

It helps protect cells from damage caused by oxidative stress

Reduction of oxidative stress was achieved by increasing levels of endogenous and exogenous antioxidants and by stabilising mitochondrial energy production