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Grade E = Expert consensus or clinical experience ACC/AHA In 2019, the ACC and AHA published Guidelines on Primary Prevention of Cardiovascular Disease, suggesting that GLP-1 RA may help reduce CVD risk in patients with T2DM who require glucose-lowering medications despite lifestyle changes and use of metformin (Class 2a, Level of Evidence (LoE) B-R) [42]

Valencia J, Velilla C, Urpegui A, Alvarez I, Llorens MA, Coronel P, et al

N., Sudini, H

These improvements in metabolic health can reduce the risk of heart disease, stroke, and other serious health conditions related to obesity

May reduce the efficacy of immunosuppressants and potentially increase the risk of transplant rejection