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These data suggested that fibroblasts from keloids and normal skins were arrested in G0/G1 phase by serum-limitation culture and showed the senescent phenotype, moreover, keloid fibroblasts were susceptible to senescent stimulus

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The downstream targets of Nrf2 can be classified into three categories, which are the regulation of iron metabolism, intermediary metabolism, and glutathione synthesis/metabolism ( 3.2 Ferroptosis in HSCs Hematopoietic stem cells (HSCs) are the source of human blood cells because they have the capacity to self-renew, self-repair, and rebuild hematopoietic function