2012;38:21 Mazziotti G, Giustina A, Canalis E, Bilezikian JP
When this system becomes disrupted, patients may experience symptoms such as abdominal pain, bloating, diarrhea, constipation, urgency, food sensitivity patterns, fatigue, or systemic inflammatory complaints
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However, TNF- has a concentration-dependent effect and exerts neuroprotective effects at physiological levels through facilitating synaptic plasticity and myelination, suggesting that dysregulated rather than basal TNF- signalling is pathogenic [184]