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23,24 A phase IIb RCT including 283 noncirrhotic NASH patients compared OCA and placebo groups for 72 weeks and showed that more patients in the OCA group had improvement in scored liver histology without progression of fibrosis from baseline

A JAMA Network Open retrospective cohort study of 125,474 adults with overweight or obesity: Patients with T2DM: 46.5% discontinued by year one 64.1% discontinued by year two Patients without T2DM: 64.8% discontinued by year one 84.4% discontinued by year two Nearly 85% of patients without diabetes stopped taking GLP-1s within two years

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