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had demonstrated in their study that CD133 + stem cells isolated from MCF-7 breast cancer cell lines, upon treatment with 0.001 and 0.1 M 1,25(OH) 2 D 3 , elevated the production of vitamin D receptors in the cancer stem cells by inhibiting the Wnt/-catenin signalling, concomitantly bringing down tamoxifen resistance in the MCF-7 cells [261]