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They might need shots more often

Allergies and Health Conditions People with allergies or certain health problems should let their doctor know before getting a vitamin B12 shot

Low NAD+ links to age-related diseases like cardiovascular issues, metabolic disorders, neurodegeneration, and cancer.[3][16] For example, in Alzheimer's models, NAD+ depletion exacerbates amyloid plaque formation and neuronal death

Thyroid concerns arose during drug development due to C-cell hyperplasia and medullary thyroid carcinoma seen in rodent studies

The MHRA encourages reporting of suspected adverse reactions to any injectable product through the Yellow Card scheme, contributing to ongoing safety monitoring