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References StatPearls (NCBI Bookshelf) Farzam K, Patel P

Tirzepatide was developed as a unimolecular dual agonist and moved through the SURPASS (type 2 diabetes) and SURMOUNT (obesity) Phase 3 programs to approval, becoming the first approved GLP-1/GIP dual agonist

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This decline can result from factors such as poor dietary choices, chronic stress, and environmental toxins

One peptide contains a hydrophobic sequence at its N-terminus (PFVYLI-CAND) 44 , while the other includes a positively charged, hydrophilic HIV-TAT sequence at its N-terminus (CPP-CAND) 45 (Figure