Quick notelean mass, muscle, function, etc are a concern with all routes to weight loss not just GLP-1 Lean mass is not the same as skeletal muscle When a DXA scan, bioelectrical impedance scale, or clinical trial reports lean mass, it is not measuring skeletal muscle alone
Abbreviations AAV: Adeno-associated virus AKI: Acute kidney injury ANCA: Anti-neutrophil cytoplasmic antibody ARDS: Acute respiratory distress syndrome AVV: ANCA-associated vasculitis CG: Cathepsin G CTCs: Circulating tumor cells DEK: DNA-binding protein DEK DHTI: 15, 16-Dihydrotanshinone I ECs: Endothelial cells PDG: 2-Fluoro-2-deoxy-D-glucose GM-CSF: Granulocytemacrophage colony-stimulating factor IFN-: Interferon alpha IRA: Infract-related artery JIA: Juvenile idiopathic arthritis MI: Myocardial infarction MMP-9: Matrix metalloproteinase-9 MPO: Myeloperoxidase NE: Neutrophil elastase NEFAs: Non-esterified fatty acids NETs: Neutrophil extracellular traps NOX2: NADPH oxidase 2 OSM: Oncostatin M PAD4: Peptidyl arginine deiminase 4 PAF: Platelet-activating factor Panx1: Pannexin 1 pDCs: Plasmacytoid dendritic cells PMA: Phorbol 12-myristate 13-acetate PMNs: Polymorphonuclear neutrophils PR3: Proteinase 3 RA: Rheumatoid arthritis RCC: Renal cell carcinoma rhDNase: Recombinant human deoxyribonuclease RIPK1: Receptor-interacting protein kinase 1 ROS: Reactive oxygen species Sal B: Salvianolic acid B SLE: Systemic lupus erythematosus STEMI: ST-elevation myocardial infarction SVV: Small vessel vasculitis TAN: Tumor-associated neutrophils TINs: Tumor-infiltrating neutrophils TME: Tumor microenvironment References Hidalgo A, Libby P, Soehnlein O, Aramburu IV, Papayannopoulos V, Silvestre-Roig C
But they will be, if history is any indication
Blood sugar control appears slightly better with tirzepatide in head-to-head trials, possibly due to GIPs robust insulin secretion effects
These medications slow stomach emptying, increase feelings of fullness, and directly stimulate insulin secretion in response to meals
