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The objective of this study was to compare the efficacy and safety of tirzepatide with titrated insulin degludec in individuals with type 2 diabetes who had inadequate glycemic control despite treatment with metformin alone or in combination with SGLT2 inhibitors.In this phase 3 study, participants aged 18 years or older, with a baseline glycated hemoglobin (HbA1c) of 7.0-10.5%, body mass index of at least 25 kg/m2, stable weight, and no prior insulin treatment, were enrolled across multiple centers in 13 countries

Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis