( C ) Schematic of IRI protocol and ( D ) percentage of LVDP recovery of isolated WT mouse hearts with the sAC inhibitor KH7 (20 mol/L) or the tmAC inhibitor Ddox (50 mol/L) prior to perfusion with buffer only (Cntl), scrambled(2836), GLP-1(2836), or GLP-1 ( n = 3/group)
Classification of MASLD, MetALD, ALD and no SLD by the algorithm also showed high correlation with chart review, with a kappa of 0.87 (95% CI 0.82-0.91), and identified 436,974 (53.4%) of participants to have SLD, compared to ICD 9/10 codes in only 23,218 (2.8%) patients
2018;154(6, Supplement 1):S-614-S-5
Acute ischemic stroke update
An alternative strategy involves engineered probiotics as living nanofactories that secrete GLP-1 analogues directly in the gut [390, 391]