Wrote or contributed to the writing of the manuscript: McCoy, Benoist, Wright, Kawas, Bule-Ghogare, Appleyard, Wayman, Harding
doi: 10.1016/j.bpg.2017.09.011
Not a treatment claim
Pathway enrichment analysis revealed that these genes were enriched in 170 signaling pathways, and the top 20 signaling pathways most closely related to AD were the following (Supplementary Table 2): AD-related pathways include neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, calcium signaling pathway, cAMP signaling pathway, MAPK signaling pathway, Ras signaling pathway, serotonergic synapse, pathways of neurodegeneration multiple diseases, Rap1 signaling pathway, AD and AGE-RAGE signaling pathway in diabetic complications
Weekly dosing protocols are being investigated as alternatives