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TF-induced thrombin cleaves C5 at a novel R947 site and forms new fragments, C5 T and C5b T (Krisinger et al., 2012)

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Current evidence suggests GHK-Cu may provide moderate adjunctive benefits in pigmentation disorder management when combined with established treatments including hydroquinone, kojic acid, or laser therapies, rather than serving as a primary depigmenting agent