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Specifically, in the leaky gut state, gut microbiota dysbiosis occurs, the expression of intestinal epithelial junction proteins (e.g., tight junction proteins) decreases, and intestinal permeability increases, forming a leaky gut (165)

Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen

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Missing data were assumed to be missing at random, and multiple imputation was performed by multivariate imputation using chained equations (38, 39)