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These pyrophosphate analogs antagonize the ability of transketolase in vitro [113] In diabetes mellitus type 2 experimental model, the role of transketolase in the reductive pentose pathway and its activation by administration of lipid soluble thiamine derivative benfotiamine is well documented and undeniable [114] and further clinical research is ongoing

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Collectively, these mTOR inhibitors demonstrate potent pharmacological activities and exhibit promising prospects for therapeutic interventions aimed at mitigating RA

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