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It stimulates the synthesis of key ECM components, including collagen I and III, elastin, and various glycosaminoglycans (GAGs), by signaling through pathways such as the TGF-/SMAD cascade

While the phenotypic insulin resistance in NAFLD would be expected to counteract insulin-mediated SREBP1c activation, a state of selective insulin resistance ensures that insulin retains its ability to promote DNL through SREBP1c while being unable to suppress gluconeogenesis [41]

These changes may indicate a higher risk of health issues, such as disruptions in kidney function, and an imbalance between oxidants and antioxidants

Kitamura T, Jansen P, Hardenbrook C, et al

Some of these adulterants, then, can also cause kidney injury