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PTL shares significant structural and mechanistic homology with LPL, as both have lid peptides that regulate access to the active site and swing open during interfacial activation

Several trials have demonstrated that GLP-1 RAs reduce cardiovascular risk in patients with type 2 diabetes mellitus and ASCVD or high cardiovascular risk and have beneficial effects on cardio-renal outcomes beyond their blood glucose-lowering effects in type 2 diabetes mellitus patients

What has not changed is the underlying evidence base

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A peptide that suppresses appetite and improves hepatic glucose output does not rebuild the metabolic machinery that chronic inactivity has degraded