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Electrostatic steering of the C201- S -sulfonate to the Rhod active site is important for activity The failure of C408A CstB to turn over, coupled with the binding of sulfite to the Rhod domain of both C408S mutants, suggests the possibility that the strongly negatively charged S -sulfonated C201 is captured via electrostatic steering and subsequently processed by the C-terminal Rhod domain

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Table 1), and the recurrence rate after biopsy or excision is high