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There were no cases of glucose intolerance, insulin resistance, edema (fluid retention), joint pain, carpal tunnel syndrome, or other manifestations of excess growth hormone activity

doi: 10.1016/j.repc.2017.07.003 42

On May 1, 2026, Health Canada authorized a second generic semaglutide injection, filed by Canadian-based Apotex, and stated that seven other submissions from different companies remained under review [Source: canada.ca/en/health-canada/news/2026/05/canada-approves-second-generic-semaglutide-the-first-g7-country-to-do-so.html]

Nutritional guidance emphasizing balanced fat intake can also support healthy bile flow and reduce stone formation risk

Yang Y, Zhang J, Wu S, Deng Y, Wang S, Xie L