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27,28 By slowing degradation of GLP-1, these DPP-IV inhibitors enhance the action of endogenous GLP-1 to activate vagal sensory neurons that compose the hepato-portal glucose sensor
Clinical trials have not identified mood disorders as significant adverse effects, though individual experiences vary and warrant clinical assessment
Its not a substitute for evidence-based approaches
When paired with an individualized low-calorie, low-fat diet and a consistent exercise program, GLP-1 therapy can help improve various health markers in overweight adults including high blood pressure, diabetes, or high cholesterol reducing cardiovascular risk and improving metabolic health
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