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This is why it is important to understand what additional weight management efforts patients pursue in real-world settings after discontinuing semaglutide or tirzepatide, and whether long-term weight changes after discontinuation follow the patterns reported in randomized clinical trials. Hamlet Gasoyan, DS, PhD, MPH According to the researchers, a potential reason for the difference may be that people often continue their treatment journey in other ways

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doi: 10.1186/s12967-025-06927-z 30