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Proc Natl Acad Sci, USA

Non-invasive Alternative: Nasal sprays provide a less invasive option than injections, potentially improving adherence in long-term research protocols

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Activation of natural immunity involves innate immune cells, such as macrophages, monocytes, NK cells and neutrophils, and their secretion of pro-inflammatory cytokines or induction of NACHT, LRR and PYD structural domain protein 3 (NLRP3) inflammasome activation, leading to a series of amplified inflammatory responses (12, 13)