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MTs, which are highly expressed in the nucleus during oxidative stress, act as both zinc reservoirs and redox buffers 42

The methionine cycle metabolites are further reduced compounding the effects of trisomy 21

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doi: 10.1038/s41587-019-0224-x 408 ZhouY.SongW

These drugs are neurotransmitter regulators that can only temporarily relieve symptoms but cannot stop or reverse the progression of AD (Salomone et al., 2012)